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Gastroretentive Floating Drug Delivery System of Zaleplon Tablets de Kannan Raman Gomathi Swaminathan(Ks Omniscriptum Publishing) (en Inglés)
Subramani M.,Swaminathan Gomathi,Raman Kannan (Autor)
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Ks Omniscriptum Publishing
· Tapa Blanda
Gastroretentive Floating Drug Delivery System of Zaleplon Tablets de Kannan Raman Gomathi Swaminathan(Ks Omniscriptum Publishing) (en Inglés) - Subramani M.,Swaminathan Gomathi,Raman Kannan
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Reseña del libro "Gastroretentive Floating Drug Delivery System of Zaleplon Tablets de Kannan Raman Gomathi Swaminathan(Ks Omniscriptum Publishing) (en Inglés)"
Floating Drug Delivery Systems are retained in the stomach for a longer time and assist in improving the oral controlled delivery of drugs that have an absorption window in the particular region of the GI tract as well as for controlling the release of the drug having site-specific absorption limitationZaleplon is a highly effective sedative-hypnotic that was used as a model drug to develop a controlled-release formulation. Zaleplon exhibits pH-dependent solubility. It is more soluble in acidic pH and slightly soluble in neutral or alkaline conditions (intestinal environment). Hence an attempt was made to develop a gastroretentive delivery system Zaleplon which increased the bioavailability of Zaleplon and also reduced the frequency of administration, thereby improving patient compliance and therapeutic efficacy.
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