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clinical pharmacology in the elderly: reference ranges and biological variations after repeated measurements (en Inglés)
Hans-Peter Breuel
(Autor)
·
J. Kuhlmann
(Prefacio de)
·
Springer
· Tapa Blanda
clinical pharmacology in the elderly: reference ranges and biological variations after repeated measurements (en Inglés) - Kuhlmann, J. ; Heine, P. R. ; Breuel, Hans-Peter
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Reseña del libro "clinical pharmacology in the elderly: reference ranges and biological variations after repeated measurements (en Inglés)"
The appropriate and rational use of drugs by the elderly is a matter of growing medical and social concern. Persons aged 65 years and older constitute about 12%-15% of the population in the Western world, and the total number of the elderly will increase significantly in the coming years. This population accounts for 30% of all the prescription drugs used. Aging, specifically the transition from middle to old age, is a complex process. From the perspective of clinical pharmacology, these pathophysiological changes may reasonably be expected to alter responsiveness to drugs. The age-related differences in response to drugs can arise from alterations in pharmacokinetics or pharmacodynamics. This makes it mandatory that clinical pharma- cological studies be carried out in the elderly during extended phase I studies. The older the population likely to use the drug, the more important it is to include the very old. It is also important not to exclude ....: ''lecessarily patients with concomitant illnesses; it is only by observing, such patients that drug-disease interactions can be detected. Reports from surveillance systems have greatly increased our awareness of problems associated with drug therapy in old age.
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